Based on comprehensive study of new data of outcrops by edge of the Hefei basin, seismic sections in the basin, isotopic age and magnetotelluric sounding, etc., this paper suggests that the basement of the Hefei basin, in Mesozoic and Cenozoic, is stacked and compounded by deferent tectonic types of basements. The pre-Upper Paleozoic basement is divided by the Liu’an Fault, north of which is crystalline basement of continental and transitional crust of the North China Plate and Neoproterozoic-Lower Paleozoic sedimentary basement formed in the North China Craton and its passive continental margin basin. To the south of the Lin’an Fault is crystalline basement of the Dabie Massif and Neoproterozoic-Lower Paleozoic metamorphic basement formed in the Beihuaiyang Retroarc Basin. The Upper Paleozoic basement rocks under the Mesozoic and Cenozoic strata in the Hefei basin belongs to the deposits in retroarc foreland basin. The Liu’an Fault is the suture of arc-continent collision between the North Dabie Arc-Beihuaiyang Retroarc Basin of Neoproterozoic-Ealy Paleozoic and the North China Plate in the Hefei basin, which collided in late Early Paleozoic to early Late Paleozoic.