The phenomena of foreland sedimentation and deformation around the Tan-Lu fault zone showed a lot of information on its synorogenic activities. The depositional center belts and marginal facies of the Jurassic strata near the fault zone in east part of the Hefei Basin suggested that the Zhangbaling uplifted belt, occupied recently by the Tan-Lu fault zone, moved to the east of the basin before Early Jurassic. The sandstone detrital composition and detrital muscovite electronic probe analyses demonstrated that foreland sediments of the Huangmaqing and Xiangshan Groups with arcuate distribution were autochthonous in the Lower Yangtze region, and their provenance was the Dabie-Sulu orogenic belt, which implyed that the Tan-Lu fault appeared during the orogeny. The intensive foreland fold-and-thrust belts occurred on the both sides of the Dabie-Sulu orogenic belt. Increasing of the Indosinian thrusts in pre-Jurassic basement of the Hefei Basin near the Tan-Lu fault zone indicated synorogenic activities of the fault zone. Curving of the foreland structural strikes towards the Tan-Lu fault zone demonstrated that their development was affected by sinistral strike-slip movement on the fault zone. All characteristics of the foreland sedimentation and deformation suggested that the fault zone was derived from collision orogeny of the North and South China plates as an intracontinental transfer fault zone. The eastern wall of the fault zone was an active wall, and an obvious anti-clockwise rotation took place during its synorogenic movement. The unique arcuate thrust-nappe structures in Xuzhou-Suzhou area suggested a sinistral displacement about 350 km of the synorogenic fault zone. The fault zone extended northwards further during the second transcurrent faulting in Early Cretaceous and sinistral displacement of ca 200 km took place again.