The Ganjiang fault zone in Jiangxi province, composed of NNE-striking, NE-striking and NW-striking fault groups, was mainly a large scale sinistral strike slip fault; in addition, the dextral shearing and extention of the fault could be observed. Based on seismic, MT, drilling data and field survey of petroleum exploration, the paper illustrated geological and geophysical features of the fault. Three stages of the Cretaceous basins’ developing, controlled by the fault, could be distinguished: 1)the Early Cretaceous pull-apart basins controlled by the sinistral strike slipping, with sedimentary record being the Lengshuiwu Formation; 2)the trans-releasing basin in early Late Cretaceous occurring in transformation from sinistral to dextral strike slipping, the sedimentary record being the Zhoujiadian Formation; and 3)the stretch basin in middle-late period of Late Cretaceous controlled by an oblique normal faulting, with the Nanxiong Formation deposited. Under a global tectonic setting of the Pacific plate obliquely subducted the Eurasia plate since Jurassic, the Ganjiang fault experienced three-stage evolution during Juro-Cretaceous. It was a transcompressional one in Early-Middle Jurassic, whose developing of the NE-striking faults related to the Yan shanian intracontinental orogeny in South China. It became a syn-orogenic sinistral strike slip one in Late Jurassic and Early Cretaceous. The regional sinistral shearing field resulted from two events. One was closure of the Su-Lu ocean, and concurrently, an oblique convergent-shearing orogeny occurred along the Tan-Lu fault. Another was an oblique convergent-shearing orogeny along the Changle-Nan’ao fault in SE coast area. The dextral strike slip and extension in Late Cretaceous was a reflection of the Yan shanian orogens’ collapse. The evolution of the NNE-striking faults were constained by the sinistral shearing of the Tan-Lu fault, so that the sinistral strike slipping of the Ganjiang fault had a tendency of "stronger and earlier in north segment, gentle and late in south segment". The activity modes of the Ganjiang fault in Cretaceous were coincident with that of the Tan-Lu fault, and the former could be regarded as a southward extension of the Tan-Lu fault.