The Shimenkou CuFeAuS deposit were presented by the upper stratiform ore beds and the lower disseminatedveinlet ores. The δ34 S values of barite in the upper stratiform ore beds ranged from ＋1410‰ to ＋1890‰.The δ34 S values of pyrite and galena in the upper stratiform ore beds ranged from ＋350 to ＋584‰，that of pyrite in the lower disseminatedveinlet ores +480‰ to +680‰. The δ18 O of quartz in the lower disseminatedveinlet ores ranged from ＋143‰ to ＋185‰， the δ30Si of that from -03‰ to -02‰. the Re/Os of pyrite in the lower disseminatedveinlet ores ranged from 78342 to 175540，that in the upper stratiform ore beds from 62298 to 169545. The average δ34 S，Re/Os and the measured temperatures (from 249 ℃to 97 ℃)of fluid inclusions decrease gradually，with the average  206 Pb/204 Pb， 207 Pb/204 Pb， 208 Pb/204 Pb  and Os总，Re， 187 Re  contents increaseing progressively，from the lower disseminatedveinlet ores to the upper stratiform ore beds. The ReOs isotopic model age of pyrites in the ores was 303±33 Ma. The geologicalgeochemical features show the Shimenkou CuFeSAu deposit is of submarine sedimentary exhalative origin.