The Shimenkou CuFeAuS deposit were presented by the upper stratiform ore beds and the lower disseminatedveinlet ores. The δ34 S values of barite in the upper stratiform ore beds ranged from ＋1410‰ to ＋1890‰.The δ34 S values of pyrite and galena in the upper stratiform ore beds ranged from ＋350 to ＋584‰，that of pyrite in the lower disseminatedveinlet ores +480‰ to +680‰. The δ18 O of quartz in the lower disseminatedveinlet ores ranged from ＋143‰ to ＋185‰， the δ30Si of that from -03‰ to -02‰. the Re/Os of pyrite in the lower disseminatedveinlet ores ranged from 78342 to 175540，that in the upper stratiform ore beds from 62298 to 169545. The average δ34 S，Re/Os and the measured temperatures (from 249 ℃to 97 ℃)of fluid inclusions decrease gradually，with the average 206 Pb/204 Pb， 207 Pb/204 Pb， 208 Pb/204 Pb and Os总，Re， 187 Re contents increaseing progressively，from the lower disseminatedveinlet ores to the upper stratiform ore beds. The ReOs isotopic model age of pyrites in the ores was 303±33 Ma. The geologicalgeochemical features show the Shimenkou CuFeSAu deposit is of submarine sedimentary exhalative origin.