Many isotopic ages from the TanLu Fault Zone effectively constrains evolution and relative geodynamic processes of the fault zone. Muscovite 40Ar/39Ar deformation ages of 238～236 Ma from the earlier strikeslip belt demonstrate that the fault zone started at the deepsubduction stage during collision of the North and South China Cratons，and support the synorogenic，intracontinental transform fault model. The older，obtained muscovite 40Ar/39Ar cooling ages from the sinistral ductile shear belt of Late Mesozoic range from 162 Ma to 150 Ma. The dating results suggest that the second phase of sinistral motion along the fault zone took place under regional transpressional regime in the earliest Late Jurassic or between Middle and Late Jurassic. This event should represent beginning of the circumPacific regime in East China. A series of zircon LAICPMS ages from plutons and volcanic rocks along the fault zone show that the earliest magmatism related to extension in the fault zone started as old as 136 Ma. Stratigraphic ages of the strata in the rift basins controlled by the TanLu Fault Zone suggest that extension along the fault zone started in the earliest Early Cretaceous(ca. 145 Ma). This agrees with the transition time to tensile geodynamic setting in East China. Many feldspar 40Ar/39Ar ages and apatite FT ages indicate that the TanLu Fault Zone was still involved in normal faulting during Late Cretaceous and Paleogene.