Based on drilling data, logging information, 2D seismic data, geological map at a scale of 1∶100 000 and Digital Elevation Model （DEM） data, guided by fault related folding theory, this paper mainly analyzes the geometry and kinematics of Pamir frontal thrust zone, which is located at northeastern margin of Pamir salient. Pamir salient as the key area that reveals the formation and evolution of Tibet Plateau, provides detailed information of collision and orogeny. Therefore, it is significant determining the development of key structures. Our study suggests that Pamir frontal thrust can be divided into 2 segments along the fault strike and 2 dip domains. West segment is strongly deformed while east segment is not and the structural styles are quite different among two segments. The collision began at Early Miocene in this area and strongly deformed after Pliocene. Pamir frontal thrust in this area initiated at Quaternary and is characterized by episodic activity. Analyzed by fault related folding theory, the shortening from Miocene to Pliocene is more than 9.47 km, the shortening during Quaternary is at least 11.65 km. The structure of Quaternary growth strata is controlled by imbricates and Pamir frontal thrust. Evolution of the key structures can be determined by finding out relation between shallow and deep structure. It is an effective method in complicated structural analysis.