The 2370 layer of Miocene Zhujiang Formation is one of the major reservoir in Lufeng A area, Pearl River Mouth Basin. But the large thickness difference and complicated distribution of sandstone seriously restrict the field exploration and deployment. This paper integrate s the seismic data, logging and geological data, and concludes that the P-wave impedance and VP/VS are the sensitive parameters of lithology identification. The distribution of 2370 layer of sandstone is described by using prestack simultaneous inversion method, and the north area is thicker than the south on the whole. On the basis of seismic amplitude and the properties of frequency division and prestack inversion, the relationship between the property and porosity is analyzed by using multi-attribute inversion method. The reservoir identification parameters are six properties, which contain the density, VP/VS, seismic derivative, LR, VP and 25~30 Hz seismic frequency. The results of multi-attribute inversion show porosity generally above 18% in the northeast and the west of the study area, which belongs to the reservoir type of beach sand and dam sand, and it is a thick layer. In the middle and east part, the porosity is 10%~18%, which is the influence of the interaction between the sandstone and mudstone. Porosity prediction results are consistent with the drilling results of the same period, and the predicted coincidence rate is more than 75%. Multi-attribute inversion method shows good effectiveness and practicability in reservoir prediction of the study area, and it also has reference significance to the similar area of reservoir prediction.