The magmatic activity was very fierce and frequent in the Bengbu area during Mesozoic, which is mainly acidic magma activity and mafic dikes only intruded in few areas. U-Pb chronology analyses LA-ICP-MS U-Pb isotopic dating has been conducted on zircon grains collected from the lamprophyre dyke from Bengbu-Wuhe area. The zircon grains are usually subhedral or rounded and probably captured from the wall rocks during magma ascending. Three peak ages of captured zircons are 3 100 Ma, 2 500 Ma and 2 000 Ma, respectively, which coincide well with the ages of the Wuhe complex that is the basement of the North China Craton in Bengbu area. Because of the lack ages of Neoproterozoic and Triassic period probably indicate that there is no subduction of continental crust material beneath the Bengbu-Wuhe area. However, two new zircon grains yield weighted mean age of 156±8 Ma, which indicated the intrusion of the lamprophyre occurred during Late Jurassic. There is a widespread northward thrust-nappe structure in Bengbu area which reworked the lamprophyre veins and caused the foliation formed. Therefore the age of the lamprophyre veins also constrains the lower age limit of this deformation event.