We report LA-ICP MS zircon U-Pb ages from magmatic rocks of Zhaojikou lead-zinc deposit in Dongzhi County, southern Anhui Province. The zircon U-Pb isotopic ages of Daicun granodiorite and granitic porphyry dyke in the deposit are 145.5±1.3 Ma and 143.5±4.3 Ma, respectively. Moreover, the ages of fine-grain diorite dyke are 129.0±2.3 Ma and 128.4±2.7 Ma. The former are the products of the same period magmatism, the later is one of the ore-bearing rocks and lead-zinc mineralization is closely related to this period magmatism. Many inherited zircons occurred in the intermediate-acid intrusive bodies and dykes of the deposit, which imply numerous diagenetic materials were come from the ancient crustal basement. The isotopic ages of inherited zircon focused on 890～740 Ma reflects the tectonic-magmatic event took place between the Cathaysia plate and the Yangtze plate in the Jinning period. The ages of small amount of zircons in the intrusive rocks are more than 1 500 Ma even 2 500 Ma, which indicates the continental crust in the region has Early Proterozoic or Archean basement.